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Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
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Insights and challenges on animal models for progressive multiple sclerosis

Isabella F Nalepa1,2, Nicolai O Haahr1,3, Vasileios Bekiaris2

  • 1Preclinical Fluid Biomarkers and Occupancy, H. Lundbeck A/S, Valby, Denmark.

Journal of Neuroinflammation
|April 14, 2026
PubMed
Summary

No abstract available in PubMed .

Keywords:
Animal ModelsCuprizoneEAEExperimental Autoimmune EncephalomyelitisLysolecithinNeuroimmunologyProgressive Multiple SclerosisTheiler’s murine encephalomyelitis virus

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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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