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Updated: Feb 13, 2026

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
Published on: June 14, 2024
CD45RO regulates the HIV-1 gp120-mediated apoptosis of T cells by activating Lck
Kelei Li1,2,3, Zhe Cong1,2,3, Zhuoying Peng1,2,3
1Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS), No. 5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China.
Abstract:
CD45 has been reported to regulate the HIV-1 gp120-induced apoptosis of Jurkat cells. Here, we demonstrate that the extracellular domain of CD45 plays an important role in this function. We observed that CD45RO-transfected cells, but not cells transfected with other CD45 isoforms, underwent significant apoptosis induced by gp120. However, a CD45RA-transfected cell line treated with an O-glycan inhibitor was able to undergo apoptosis. The role of the extracellular domain of CD45 was further confirmed using CD45 isoform-transfected cell lines by analyzing the phosphorylation of Lck, which is a direct substrate of CD45 tyrosine phosphatase, and by using an Lck inhibitor. These results suggest that CD45RO modulates HIV-1 gp120-induced apoptosis by regulating the activity of Lck.
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