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Updated: Feb 13, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

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Discovery of novel CDK inhibitors via scaffold hopping from CAN508

Liandong Jing1, Yanbo Tang1, Zhiyan Xiao1

  • 1Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Bioorganic & Medicinal Chemistry Letters
|March 19, 2018
PubMed

Keywords:
CAN508CDK2CDK9Pyrazolo[3,4-b]pyridineScaffold hoppingSelectivity

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