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Updated: Feb 13, 2026

Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C. elegans
Published on: November 15, 2011
Microtubules and axon regeneration in C. elegans
1Barshop Institute for Longevity and Aging Studies, Department of Cell Systems and Anatomy, Department of Molecular Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Abstract:
Axon regeneration is a fundamental and conserved process that allows the nervous system to repair circuits after trauma. Due to its conserved genome, transparent body, and relatively simple neuroanatomy, C. elegans has become a powerful model organism for studying the cellular and molecular mechanisms underlying axon regeneration. Various studies from different model organisms have found microtubule dynamics to be pivotal to axon regrowth. In this review, we will discuss the latest findings on how microtubule dynamics are regulated during axon regeneration in C. elegans. Understanding the mechanisms of axon regeneration will aid in the development of more effective therapeutic strategies for treatments of diseases involving disconnection of axons, such as spinal cord injury and stroke.
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