Related Experiment Video

Updated: Feb 13, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
07:33

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

Published on: May 21, 2010

37.3K

Multi-centre prospective internal and external evaluation of the Brompton Harefield Infection Score (BHIS)

Melissa Rochon1,2, Julian We Jarman2, Joseph Gabriel3

  • 1Harefield Hospital, Harefield, UK.

Journal of Infection Prevention
|March 20, 2018
PubMed

Insights

The Brompton Harefield Infection Score (BHIS) accurately predicts surgical site infections (SSI) after coronary artery bypass grafting (CABG). This prospective study validated BHIS, confirming its utility for identifying high-risk patients and improving outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Infectious Disease Epidemiology
  • Clinical Risk Prediction

Background:

  • The Brompton Harefield Infection Score (BHIS) was previously developed to predict surgical site infection (SSI) risk following coronary artery bypass grafting (CABG).
  • BHIS stratifies patients into risk groups based on factors including gender, diabetes, BMI, ejection fraction, and emergency status.
  • The score's predictive performance required further validation.

Purpose of the Study:

  • To prospectively evaluate the internal and external validity of the BHIS.
  • To confirm the BHIS's accuracy in predicting SSI after CABG across multiple institutions.

Main Methods:

  • A multi-centre prospective study was conducted across three tertiary centres from October 2012 to November 2015.
  • Surgical site infection (SSI) classification followed the Public Health England protocol.
  • Predictive accuracy was assessed using receiver operating characteristic (ROC) curves.

Main Results:

  • Out of 4308 CABG patients, 168 (3.9%) developed an SSI.
  • Patients were categorized by BHIS: 65% low risk (0-1), 26% medium risk (2-3), and 8% high risk (≥4).
  • The area under the ROC curve ranged from 0.702-0.785, with an overall AUC of 0.709.

Conclusions:

  • The BHIS is a validated score for predicting SSI risk in CABG patients.
  • Internal and external evaluations confirm BHIS utility.
  • Clinicians can use BHIS to proactively identify high-risk individuals and enhance patient outcomes.
Abstract

Keywords:
Surgical site infectionstatisticssurveillance

More Related Videos

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives10:26

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

11.8K
Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Related Concept Videos

Internal and External Forces01:12

Internal and External Forces

Newton's first law states that a net external force causes a change in motion. External forces act on an object or system, originating outside of the object or system. In contrast, internal forces originate inside the system of interest and do not lead to any acceleration. In simpler words, internal forces are forces that act on one part of an object and are exerted by another part of the same object. External forces are forces that act on an object due to some other object. Therefore, when...
16.4K
External and Internal Respiration01:24

External and Internal Respiration

External respiration occurs in the lungs, and it is the first step in the journey of oxygen inside the body. When we inhale, oxygen enters our lungs and diffuses across the thin alveolar membrane. The alveoli are tiny, air-filled sacs that provide a vast surface area for gas exchange. Oxygen in the alveoli has a higher partial pressure (105 mmHg) than in the adjacent pulmonary capillaries (40 mmHg), establishing a pressure gradient. As a result, oxygen molecules move from the alveoli into the...
7.8K
Internal Energy02:00

Internal Energy

The total of all possible kinds of energy present in a substance is called the internal energy (U), sometimes symbolized as E. Suppose a system with initial internal energy, Uinitial, undergoes a change in energy (transfer of work or heat), and the final internal energy of the system is Ufinal. Change in internal energy equals the difference between Ufinal and Uinitial.
36.9K
Introduction to z Scores01:06

Introduction to z Scores

A z score (or standardized value) is measured in units of the standard deviation. It tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a zero z score. It is important to note that the mean of the z scores is zero, and the standard deviation is one.
z scores...
11.3K
Introduction to z Scores01:05

Introduction to z Scores

A z score (or standardized value) is measured in units of the standard deviation. It indicates how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a zero z score. It is important to note that the mean of the z scores is zero, and the standard deviation is one.
z scores...
1.4K
z Scores and Area Under the Curve01:17

z Scores and Area Under the Curve

z scores are the standardized values obtained after converting a normal distribution into a standard normal distribution. A z score is measured in units of the standard deviation. The z score tells you how many standard deviations the value x is above (to the right of) or below (to the left of) the mean, μ. Values of x that are larger than the mean have positive z scores, and values of x that are smaller than the mean have negative z scores. If x equals the mean, then x has a z score of...
19.6K