Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Real Time RT-PCR02:57

Real Time RT-PCR

65.4K
Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
65.4K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

75.9K
Oxidation–Reduction Reactions
75.9K
Computed Tomography01:10

Computed Tomography

8.9K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.9K
Oxymercuration-Reduction of Alkenes02:36

Oxymercuration-Reduction of Alkenes

9.4K
Oxymercuration–reduction of alkenes is one of the major reactions converting alkenes to alcohols. It involves the hydration of alkenes with mercuric acetate in a mixture of tetrahydrofuran and water, forming an organomercury adduct. This is followed by a demercuration step in which the adduct is reduced to an alcohol using sodium borohydride.
9.4K
Block Diagram Reduction01:22

Block Diagram Reduction

574
The process of deriving the transfer function of a control system often involves reducing its block diagram to a single block. This simplification can be achieved through a series of strategic operations, including relocating branch points and comparators. These operations preserve the overall function of the system while allowing for easier manipulation and combination of blocks.
The first step in this process is the identification and relocation of a branch point. A branch point, where a...
574
Phase I Reactions: Reductive Reactions01:27

Phase I Reactions: Reductive Reactions

618
Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
618

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Spectroscopic correlation tomography (SpCT) for visualization of spatial correlations in volumetric OCT scans.

Biomedical optics express·2026
Same author

Real-time processing of high-throughput quantitative phase microscopy data using a Jetson Orin Nano.

Biophotonics discovery·2026
Same author

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy <i>in vivo</i> enabled by absorbing dye molecules.

Optica·2026
Same author

Prospective Identification of Dysplasia in Barrett's Esophagus With Combined Optical Coherence Tomography and Light Scattering Measurements.

Journal of biophotonics·2025
Same author

Spectroscopic analysis of volumetric OCT data for the automated measurement of scatterer size.

Journal of the Optical Society of America. A, Optics, image science, and vision·2025
Same author

Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging for <i>in vivo</i> murine skin.

Optics letters·2025

Related Experiment Video

Updated: Feb 13, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K

Real-time speckle reduction in optical coherence tomography using the dual window method.

Yang Zhao1, Kengyeh K Chu1, Will J Eldridge1

  • 1Duke University, Biomedical Engineering Department, Durham, NC 27708, USA.

Biomedical Optics Express
|March 20, 2018
PubMed
Summary

This study introduces a dual window (DW) method for reducing speckle noise in optical coherence tomography (OCT) images. The technique improves image quality by enhancing contrast-to-noise ratio without needing extra hardware.

Keywords:
(030.6140) Speckle(110.4500) Optical coherence tomography(120.3180) Interferometry

More Related Videos

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
09:20

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

11.5K
Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
07:28

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Published on: November 19, 2012

15.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
10:46

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

19.3K
Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
09:20

Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes

Published on: February 8, 2018

11.5K
Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
07:28

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Published on: November 19, 2012

15.7K

Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology
  • Signal Processing

Background:

  • Speckle noise is an inherent artifact in optical coherence tomography (OCT) that degrades image quality and reduces contrast.
  • Effective speckle reduction is crucial for accurate interpretation and diagnosis using OCT imaging.

Purpose of the Study:

  • To present a novel frequency compounding speckle reduction technique for OCT images.
  • To evaluate the effectiveness of the dual window (DW) method for speckle noise reduction.

Main Methods:

  • Implementation of the dual window (DW) method for frequency compounding.
  • Evaluation of speckle reduction performance by measuring contrast-to-noise ratio (CNR) and axial resolution.
  • Demonstration of real-time processing using a graphics processing unit (GPU).

Main Results:

  • The DW method achieved approximately 25% improvement in contrast-to-noise ratio (CNR).
  • A minimal loss of approximately 17% in axial resolution was observed.
  • Real-time speckle reduction was demonstrated at a B-scan rate of ~21 frames per second.

Conclusions:

  • The DW method effectively reduces speckle noise in OCT images, enhancing CNR with minimal impact on axial resolution.
  • The technique is compatible with existing OCT systems, requiring no hardware modifications.
  • The DW method is suitable for both real-time OCT imaging and post-processing applications.