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Related Experiment Video

Updated: Feb 13, 2026

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
05:46

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

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Hemorrhagic choroidal melanoma.

Patrick Oellers1, Natalie Wolkow2, Frederick A Jakobiec2

  • 1Retina Service, Department of Ophthalmology, Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.

American Journal of Ophthalmology Case Reports
|March 20, 2018
PubMed
Summary

Hemorrhagic choroidal melanoma, a rare condition, can result from tumor rupture through Bruch's membrane. This clinical presentation highlights the need for high suspicion in diagnosing this ocular melanoma.

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Choroidal melanoma is a rare intraocular malignancy.
  • Hemorrhagic presentation of choroidal melanoma is uncommon.

Purpose of the Study:

  • To illustrate the clinicopathologic correlation of a hemorrhagic choroidal melanoma.
  • To describe a rare case of choroidal melanoma with significant hemorrhage.

Main Methods:

  • Case report of a 52-year-old patient with a large choroidal mass and hemorrhage.
  • Enucleation of the affected eye for histopathological examination.
  • Analysis of tumor cells (MART1 positive, epithelioid type) and their relationship with Bruch's membrane.

Main Results:

  • Histopathology confirmed epithelioid-type MART1 positive choroidal melanoma.
Keywords:
Choroidal melanomaHemorrhagic melanoma

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  • Tumor rupture through Bruch's membrane was identified.
  • Vascular compression and massive hemorrhage into subretinal space, retina, and vitreous were observed.

    • Conclusions:

    • Tumor rupture through Bruch's membrane can cause a tourniquet effect, leading to massive hemorrhage in choroidal melanoma.
    • This case underscores the importance of clinical suspicion for diagnosing hemorrhagic choroidal melanoma.
    • Understanding the mechanism of hemorrhage is crucial for patient management.