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Updated: Feb 13, 2026

Osteoclast Derivation from Mouse Bone Marrow
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SPACEFLIGHT EFFECTS ON GLIAL CELLS OF M4USE B0ONEMARROW.

T V Povvsheva, Yu A Chelyshev

    Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
    |March 20, 2018
    PubMed
    Summary

    Spaceflight alters myelin in mouse spinal cords, indicated by changes in specific cell markers. Some recovery of myelin-producing cells was observed after 7 days of deadaptation to Earth.

    Area of Science:

    • Neuroscience
    • Space Biology
    • Immunohistochemistry

    Background:

    • Spaceflight is known to induce physiological changes.
    • The effects of microgravity on the central nervous system, particularly myelin, require further investigation.

    Purpose of the Study:

    • To investigate the impact of spaceflight on myelin-producing cells in the mouse lumbar spinal cord.
    • To assess the potential for recovery of myelin following deadaptation to Earth's gravity.

    Main Methods:

    • Immunohistochemistry was employed to analyze lumbar spinal cord tissue from C57BL/6N mice.
    • Analysis was conducted on day 30 of spaceflight, with and without a 7-day deadaptation period.

    Main Results:

    • Spaceflight led to an increased number of S100B+ cells and decreased populations of GFAP, Olig2, PO, and Krox24 positive cells in specific spinal cord regions.

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  • Reduced OSP fluorescence density was observed in ventral channels.
  • Elevated expression of myelin-related markers (Olig2, PO, Krox24) on day 7 of deadaptation suggested potential recovery.

    • Conclusions:

    • Spaceflight induces significant immunocytochemical changes in myelin-producing cells within the spinal cord.
    • These findings suggest that microgravity-induced myelin alterations may be rapidly normalized upon return to Earth, potentially impacting the hypogravity motor syndrome.