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Related Concept Videos

The Spinal Cord01:54

The Spinal Cord

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The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
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An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury
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RNA Sequencing and Spatial Transcriptomics in Traumatic Spinal Cord Injury (Review).

Yu A Chelyshev1, I L Ermolin2

  • 1MD, DSc, Professor, Department of Histology; Kazan Federal University, 18 Kremlyovskaya St., Kazan, the Republic of Tatarstan, 420008, Russia.

Sovremennye Tekhnologii V Meditsine
|February 13, 2025
PubMed
Summary

Single-cell and spatial transcriptomics reveal spinal cord cell types and functions. This helps understand injury mechanisms and identify therapeutic targets for restoring sensorimotor function after spinal cord injury.

Keywords:
RNA sequencingspatial transcriptomicsspinal cord injury

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Area of Science:

  • Neuroscience
  • Genomics
  • Cell Biology

Background:

  • Understanding spinal cord function requires identifying all cell types and their roles.
  • Single-cell and single-nucleus RNA sequencing are key technologies for this.
  • Spatial transcriptomics adds crucial spatial information for precise localization and analysis.

Purpose of the Study:

  • To review advances in identifying and studying cell characteristics in traumatized spinal cords.
  • To explore the potential of transcriptomic profiling for understanding spinal cord injury (SCI) mechanisms.
  • To highlight the role of these technologies in discovering therapeutic targets for neural repair.

Main Methods:

  • Single-cell RNA sequencing (scRNA-seq)
  • Single-nucleus RNA sequencing (snRNA-seq)
  • Spatial transcriptomics

Main Results:

  • Transcriptomic atlases provide insights into neural connection rearrangement and sensorimotor function restoration.
  • Identification of novel functions for nervous tissue cells.
  • Revealed molecular diversity in neurons, enabling comparison of susceptibility and regenerative potential.

Conclusions:

  • Transcriptomic profiling is essential for understanding cell-specific responses to spinal cord injury.
  • Comparing human cell populations with experimental models is crucial for determining injury causes.
  • These technologies offer powerful resources for advancing SCI research and developing targeted therapies.