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Updated: Jul 25, 2025

$Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus$

Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus

Published on: January 23, 2018

Sciatic Nerve Plastic Surgery using Autologous Adipose Tissue.

A G Velichanskaya¹, М L Bugrova², E V Pogadaeva³

¹Associate Professor, Department of Histology with Cytology and Embryology; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.

Sovremennye Tekhnologii V Meditsine

|June 30, 2023

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Autologous omental adipose tissue shows promise for sciatic nerve regeneration. When used as a graft in a silicon conduit, it stimulated nerve repair and promoted the integration of omental cells into the regenerating nerve.

Area of Science:

Regenerative Medicine
Nerve Repair
Tissue Engineering

Background:

Sciatic nerve injuries often result in significant functional deficits.
Current treatment options for large nerve gaps have limitations.
Autologous omental adipose tissue is being explored as a potential regenerative graft material.

Purpose of the Study:

To investigate structural changes of autologous omental adipose tissue within a silicon conduit.
To evaluate the efficacy of this tissue graft for sciatic nerve regeneration in a rat model.

Main Methods:

Complete sciatic nerve transection in Wistar rats.
Nerve ends placed in a silicon conduit filled with either saline (control) or autologous omental adipose tissue and saline.
Intravital labeling (PKH 26 dye) used to track omental cell integration.

Keywords:

autologous adipose tissue sciatic nerve plastic surgery sciatic nerve regeneration

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Groups with 5 mm and 2 mm diastasis, with varying postoperative periods (4-42 weeks).

Main Results:

Omental adipose tissue grafts in conduits led to satisfactory limb condition compared to saline controls.
A 2.7-fold increase in large and medium nerve fibers was observed in the omental graft group.
Omental adipose tissue underwent structural changes and was utilized over time, with omental cells integrating into the new nerve tissue.

Conclusions:

Autologous omental adipose tissue acts as a stimulating graft for post-traumatic sciatic nerve regeneration.
Omental cells contribute to the formation of the regenerating nerve structure.