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Updated: Feb 13, 2026
12:22
Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
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COMPARISON OF RETINAL PATHOLOGY VISUALIZATION IN MULTISPECTRAL SCANNING LASER IMAGING
Amit Meshi1, Tiezhu Lin1,2, Kunny Dans1
1Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Institute, University of California San Diego, La Jolla, California.
Retina (Philadelphia, Pa.)
|March 20, 2018
Summary
Spectralis imaging detected more retinal pathology than Optos imaging, particularly for epiretinal membranes and hemorrhages. This difference highlights Spectralis
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diagnostics
Background:
- Multispectral scanning laser ophthalmoscopy is crucial for visualizing retinal pathologies.
- Comparing imaging devices like Spectralis and Optos is essential for optimizing diagnostic accuracy.
- Age-related macular degeneration, diabetic retinopathy, and epiretinal membranes are common retinal conditions.
Purpose of the Study:
- To compare the visualization of retinal pathologies using multispectral scanning laser ophthalmoscopy between Spectralis and Optos devices.
- To evaluate the diagnostic performance of two different multispectral imaging systems in detecting various retinal diseases.
Main Methods:
- A retrospective cross-sectional study involving 42 eyes from 30 patients with retinal conditions.
- Retinal imaging was performed using Spectralis (3-color) and Optos (2-color) systems, alongside a color fundus camera.
- Seven masked graders assessed and marked retinal pathologies within a standardized grid.
Main Results:
- Spectralis imaging revealed a significantly larger area of detected retinal pathology (32.4% larger) compared to Optos.
- Better visualization of epiretinal membranes and retinal hemorrhages contributed to Spectralis' superior detection rates.
- Detection rates for age-related macular degeneration and diabetic retinopathy were similar across devices, but epiretinal membrane detection was higher with Spectralis.
Conclusions:
- Spectralis tricolor imaging demonstrated a higher rate of retinal pathology detection compared to Optos bicolor imaging.
- The enhanced visualization of epiretinal membranes and retinal hemorrhages by Spectralis is a key factor in its improved performance.
- These findings suggest Spectralis may offer advantages for diagnosing specific retinal conditions.
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