Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

33.9K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.9K
Epigenetic Regulation01:37

Epigenetic Regulation

3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.9K
Aging01:26

Aging

801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
801
Molecular Models02:00

Molecular Models

43.9K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.9K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

27.7K
Molecular Orbital Energy Diagrams
27.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optotransduction Pathway, Exploring Connections with Inflammation.

Biomolecules·2026
Same author

Nerve growth factor receptor p75NTR interacts with Toll-like receptor 4 and the alarmins high mobility group box 1 and nucleophosmin: a novel inflammatory mechanism in psoriasis.

The British journal of dermatology·2026
Same author

DNA methylation signatures of treatment response in medication-overuse headache.

The journal of headache and pain·2026
Same author

Epimutations in migraine and in medication overuse headache: a longitudinal study after acute medication withdrawal.

The journal of headache and pain·2026
Same author

Biologically Younger Individuals, as Identified by MARK-AGE Biological Age Scores, Display a Distinct Favourable Blood Chemistry Profile Regardless of Age.

Aging cell·2026
Same author

Whole blood DNA methylation signature of epigenetic aging in medication overuse headache.

The journal of headache and pain·2026

Related Experiment Video

Updated: Feb 13, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

323

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.

Maria Giulia Bacalini1, Claudio Franceschi1,2,3, Davide Gentilini4

  • 1IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|March 20, 2018
PubMed
Summary

The aging human liver maintains function due to stable epigenetic patterns after age 60. DNA methylation signatures reveal insights into liver aging and age acceleration, particularly with obesity.

More Related Videos

Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures
09:11

Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures

Published on: April 4, 2021

3.5K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
09:10

Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging

Published on: January 30, 2026

323
Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures
09:11

Evaluating the Impact of Hydraulic Fracturing on Streams using Microbial Molecular Signatures

Published on: April 4, 2021

3.5K
Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl
10:32

Transcriptomic Analysis of Human Retinal Surgical Specimens Using jouRNAl

Published on: August 14, 2013

8.3K

Area of Science:

  • Epigenetics
  • Gerontology
  • Hepatology

Background:

  • The liver's ability to maintain function during aging is notable, as evidenced by successful transplantation from older donors.
  • Understanding the molecular mechanisms underlying liver aging is crucial for maintaining organ health and function across the lifespan.

Purpose of the Study:

  • To investigate the epigenetic basis of liver aging by analyzing DNA methylation patterns in healthy liver donors of various ages.
  • To identify a specific DNA methylation signature for liver aging and assess its correlation with biological age acceleration and obesity.

Main Methods:

  • Analysis of DNA methylation profiles from 45 healthy liver donor biopsies using the Infinium HumanMethylation450 BeadChip.
  • Identification of age-associated differentially methylated CpG probes and a distinct liver aging signature.
  • Integration of DNA methylation data with gene expression data to explore molecular pathways involved in liver aging.

Main Results:

  • Significant remodeling of DNA methylation patterns was observed, with 8,823 age-associated differentially methylated CpG probes identified.
  • Age-related methylation changes appeared to stabilize after the age of 60.
  • A 75-region DNA methylation signature specific to liver aging was identified, capable of detecting age acceleration linked to obesity.

Conclusions:

  • The aging human liver exhibits a distinct epigenetic signature characterized by remodeling and eventual stabilization of DNA methylation patterns.
  • The identified liver aging signature is specific and can reflect biological age acceleration associated with conditions like obesity.
  • Epithelial-mesenchymal transition and Wnt signaling pathways play a significant role in human liver aging, as suggested by integrated multi-omic analyses.