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Updated: Feb 13, 2026
Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
Mapping the thickness changes on retinal layers segmented by spectral-domain optical coherence tomography using the
J J García-Medina1, M Del-Rio-Vellosillo2, A Palazón-Cabanes3
1Departamento de Oftalmología, Hospital General Universitario Reina Sofía, Murcia, España; Departamento de Oftalmología, Hospital General Universitario Morales Meseguer, Murcia, España; Departamento de Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica, Facultad de Medicina, Universidad de Murcia, Murcia, España; Red Temática de Patología Ocular OFTARED, Instituto de Salud Carlos III, Madrid, España; Instituto Murciano de Investigación Biosanitaria, Hospital Virgen de la Arrixaca (IMIB-Virgen de la Arrixaca), Murcia, España; Unidad de Investigación Oftalmológica Santiago Grisolía, Valencia, España.
Primary open-angle glaucoma (POAG) shows thickness changes in all macular retinal layers (mRLs). Inner retinal layers thin, while outer layers thicken, with varying symmetry patterns in POAG patients.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Retinal Imaging
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Early detection and monitoring of glaucoma progression are crucial for effective management.
- Optical Coherence Tomography (OCT) posterior pole program (PPP) offers detailed macular imaging.
Purpose of the Study:
- To evaluate changes in macular retinal layers (mRLs) using OCT posterior pole program (PPP) in patients with POAG.
- To compare retinal layer thickness between POAG patients and healthy controls.
- To analyze the symmetry patterns of retinal layer thickness changes.
Main Methods:
- 128 POAG patients and 103 healthy controls underwent SD-OCT with PPP (macular grid 8x8).
- Prototype software automatically segmented 9 macular retinal layers (mRLs).
- Thickness values were analyzed, and heat maps visualized differences between superior and inferior hemispheres.
Main Results:
- POAG patients exhibited thinning of the macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL).
- Thickening of the inner nuclear layer (INL) was observed in the POAG group.
- Heat maps revealed symmetrical thinning in inner retinal layers (except INL) and asymmetrical thickening in outer retinal layers.
Conclusions:
- Significant thickness alterations occur across all macular retinal layers (mRLs) in POAG, detectable by PPP.
- POAG is characterized by inner retinal layer thinning (excluding INL) and outer retinal layer thickening.
- These changes demonstrate distinct superior-inferior symmetry patterns relative to the horizontal meridian.
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