Related Experiment Video
Updated: Feb 13, 2026
05:57
Quantitative 31P NMR Analysis of Lignins and Tannins
Published on: August 2, 2021
14.8K
Development of tannin-inspired antimicrobial bioadhesives
Jinshan Guo1, Wei Sun2, Jimin Peter Kim1
1Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Acta Biomaterialia
|March 21, 2018
Summary
Researchers developed new, low-cost tannin-inspired gelatin bioadhesives. These adhesives offer strong wet tissue adhesion, tunable properties, and antimicrobial capabilities, providing a promising alternative for wound closure and tissue sealing applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surgical Innovation
Background:
- Existing tissue adhesives face limitations including high cost, cytotoxicity, and weak adhesion.
- There is a need for advanced bioadhesives with improved performance and safety profiles for surgical applications.
Purpose of the Study:
- To develop a novel family of bioadhesives inspired by the adhesive properties of plant-derived tannins.
- To create a low-cost, scalable, and effective alternative to current surgical adhesives.
Main Methods:
- A one-step Michael addition reaction between tannic acid and gelatin under oxidizing conditions.
- Crosslinking the resulting polymer network with silver nitrate to form the bioadhesive.
- Characterization of adhesion strength, gelation time, degradation, cytocompatibility, and antimicrobial activity.
Main Results:
- The tannin-inspired gelatin bioadhesives demonstrated tunable gelation times (36 seconds to 8 minutes) and controllable degradation (up to 100% within a month).
- Achieved significant wet tissue adhesion strengths, up to 3.7 times greater than fibrin glue.
- Exhibited excellent cytocompatibility and potent antibacterial and antifungal properties due to inherent antimicrobial agents.
Conclusions:
- Tannin-inspired gelatin bioadhesives represent a unique and significant advancement in bioadhesive design, leveraging natural phenolic compounds.
- These bioadhesives offer a low-cost, scalable, and effective solution for wound closure, tissue sealing, and hemostasis.
- The developed strategy is versatile and can be extended to other polymer systems for various biomedical applications.
Related Concept Videos
01:30Mechanism of Breathing I: Inspiration
3.3K
Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...
3.3K
01:28Antimicrobial Effectiveness
1.0K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.0K
01:23Antimicrobial Proteins
14.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.5K
01:43Sustainable Development
15.2K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.2K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
473
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
473
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
1.4K
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.4K