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Related Experiment Video

Updated: Feb 13, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

C-Reactive Protein Impairs Dendritic Cell Development, Maturation, and Function: Implications for Peripheral

Rachel V Jimenez¹, Tyler T Wright², Nicholas R Jones¹

¹Department of Medicine, Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, United States.

Frontiers in Immunology

|March 21, 2018

Summary

This summary is machine-generated.

C-reactive protein (CRP) suppresses dendritic cell (DC) development and function, impacting T cell responses. This suggests CRP acts as a tonic immune system suppressor, maintaining tolerance.

Keywords:

acute phase response aging autoimmunity inflammaging inflammation transgenic

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

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Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

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Published on: July 23, 2012

Area of Science:

Immunology
Molecular Biology

Background:

C-reactive protein (CRP) is a key acute phase reactant.
Emerging evidence shows CRP has physiological roles beyond acute inflammation.
CRP's baseline levels influence adaptive immunity, notably in experimental autoimmune encephalomyelitis (EAE).

Purpose of the Study:

To investigate if CRP's role in EAE involves its action on dendritic cells (DCs).
To determine the mechanism by which CRP influences DC function and T cell responses.

Main Methods:

Bone marrow-derived dendritic cells (BMDCs) were treated with CRP.
DC phenotype (MHC class II, CD86, CD40) and T cell stimulatory capacity were assessed.
Experiments utilized genetically modified mice lacking FcγRIIB and humanized FcγRIIB transgenes.

Main Results:

CRP reduced BMDC yield and suppressed the expression of MHC class II, CD86, and CD40.
CRP impaired the ability of BMDCs to stimulate T cell proliferation in vitro.
These effects were dependent on FcγRIIB expression on DCs.

Conclusions:

CRP suppresses DC development, maturation, and function.
CRP acts as a tonic suppressor of the adaptive immune system.
CRP's modulation of DCs contributes to maintaining peripheral T cell tolerance.