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Updated: Feb 13, 2026
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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
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Gene expression profile of endoscopically active and inactive ulcerative colitis: preliminary data
Cristian George Ţieranu1, Maria Dobre, Teodora Ecaterina Mănuc
1Department of Gastroenterology II, "Fundeni" Clinical Institute, Bucharest, Romania; teodora.manuc@gmail.com.
Summary
Interferon-stimulated gene 15 (ISG15) is specifically linked to remission in ulcerative colitis (UC). This finding offers potential new therapeutic targets for managing UC by understanding its gene expression profile.
Area of Science:
- Gastroenterology
- Immunology
- Molecular Biology
Background:
- Ulcerative colitis (UC) pathogenesis involves various cytokines and chemokines.
- Immune response, apoptosis, and inflammation are key processes in UC.
Purpose of the Study:
- To identify gene expression differences in UC patients versus controls.
- To compare gene expression in active UC (UCA) and remission (UCR) states.
Main Methods:
- Mucosal biopsies from 8 UC patients (4 active, 4 remission) and 3 controls.
- Polymerase chain reaction (PCR) array analyzed 84 genes related to immune function and inflammation.
Main Results:
- 17 genes were differentially expressed in active UC (UCA) compared to controls.
- 3 genes were differentially expressed in UC remission (UCR) compared to controls.
- ISG15 was specifically associated with the UC remission state.
Conclusions:
- ISG15 plays a role in innate immunity and is linked to UC remission.
- Gene profiling in UC may reveal new therapeutic targets.
- This study provides a starting point for UC gene profiling in the Romanian population.
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