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Updated: Feb 13, 2026
Orthotopic Liver Transplantation in Rats
Published on: July 1, 2012
Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry
Gianvincenzo Sparacia1,2, Roberto Cannella3, Vincenzina Lo Re4
1Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Via Tricomi, 5, 90127, Palermo, Italy. gianvincenzo.sparacia@unipa.it.
Purpose:
To assess brain-core temperature of end-stage liver disease patients undergoing orthotopic liver transplantation (OLT) using a temperature measurement technique based on the apparent diffusion coefficient of the cerebrospinal fluid in the lateral ventricles.
Materials And Methods:
The study group was composed of 19 patients with a model for end-stage liver disease (MELD) score of 23.7 who underwent MR imaging before and after OLT. MR imaging studies were performed with a 1.5T MR scanner. Brain-core temperature (T: °C) was calculated using the following equation from the apparent diffusion coefficient (D) of the cerebrospinal fluid in the lateral ventricles: [Formula: see text] measured with a DWI sequence (b value 1000 s/mm2). We compared brain-core temperature of all patients before and after OLT.
Results:
Brain-core temperature measurements were successfully taken in all patients before and after OLT. The measured brain-core temperature mean ± standard deviation was 38.67 ± 1.76 °C before OLT and 38.60 ± 0.99 °C after OLT, showing no significant difference (P = 0.643).
Conclusions:
Brain-core temperature was stable in patients undergoing OLT. DWI thermometry may provide a supplementary brain biomarker to confirm that cerebral blood flow and metabolism are stable in patients undergoing OLT.
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