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Updated: Feb 13, 2026

Assessing Intertidal Populations of the Invasive European Green Crab
Published on: September 16, 2020
WS9326H, an Antiangiogenic Pyrazolone-Bearing Peptide from an Intertidal Mudflat Actinomycete
Munhyung Bae1, Jedo Oh1, Eun Seo Bae1
1Natural Products Research Institute, College of Pharmacy , Seoul National University , Seoul 08826 , Republic of Korea.
Abstract:
WS9326H (1), a new cyclic peptide, was isolated from a mudflat-derived Streptomyces strain. Based on analysis by 1D/2D NMR, UV spectroscopy, and mass spectrometry, compound 1 was determined to have the gross structure of a cyclic heptapeptide bearing an unprecedented pyrazolone ring connected to a d-arabinitol via an amide bond. The absolute configuration of 1 was established by multistep chemical derivatizations, comprehensive NMR, and LC/MS analyses of the derivatives and quantum mechanics-based computational methods. WS9326H (1) displayed significant antiangiogenesis activity.
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