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Interrupting the FGF19-FGFR4 Axis to Therapeutically Disrupt Cancer Progression

Liwei Lang1, Austin Y Shull2, Yong Teng1,3,4

  • 1Department of Oral Biology, Augusta University, Augusta, GA 30912, United States.

Current Cancer Drug Targets
|March 21, 2018
PubMed

Insights

Fibroblast growth factor FGF19 and its receptor FGFR4 signaling drive tumor growth. Inhibiting this FGF19-FGFR4 axis is a promising strategy for cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Signal Transduction

Background:

  • The fibroblast growth factor FGF19-fibroblast growth factor receptor 4 (FGFR4) signaling pathway is crucial in tumor development.
  • Overexpression of FGF19 and FGFR4, along with hyperactivation of β-klotho, promotes cancer progression.
  • Aberrant FGF19-FGFR4 signaling drives cancer cell proliferation, apoptosis resistance, and metastasis.

Purpose of the Study:

  • To review the role of the FGF19-FGFR4 signaling pathway in cancer progression.
  • To highlight the therapeutic potential of targeting the FGF19-FGFR4 axis.

Main Methods:

  • Literature review of studies investigating the FGF19-FGFR4 signaling pathway in cancer.
  • Analysis of current therapeutic strategies targeting the FGF19-FGFR4 axis.

Main Results:

  • The FGF19-FGFR4 pathway is a key mediator of tumorigenesis through various downstream signaling cascades.
  • Inhibitors targeting FGF19-FGFR4 binding are under clinical evaluation for cancer treatment.

Conclusions:

  • Disrupting FGF19-FGFR4 communication is a promising therapeutic strategy for cancers driven by this pathway.
  • Targeting the FGF19-FGFR4 axis offers a potential avenue for novel cancer therapies.
Keywords:
FGF19FGFR4cancerdrug developmenttargetβ-klotho.

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