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Blood Transfusion01:15

Blood Transfusion

2.4K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

14.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Related Experiment Video

Updated: Feb 13, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

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Granulocyte transfusion – when and how should it be used?

Gösta Berlin1, Honar Cherif2, Folke Knutson3

  • 1Universitetssjukhuset i Linkoping - Klinisk immunlogi och transfusionsmedicin Linkoping, Sweden Universitetssjukhuset i Linkoping - Klinisk immunlogi och transfusionsmedicin Linkoping, Sweden.

Lakartidningen
|March 21, 2018
PubMed
Summary

Granulocyte transfusions may be life-saving for patients with severe infections and neutropenia unresponsive to other treatments. Daily transfusions with a high cell count are recommended, with efficacy evaluated daily.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Infectious Diseases

Background:

  • Randomized controlled trials demonstrating the clinical benefit of granulocyte transfusions are lacking.
  • Clinical experience and case studies suggest potential life-saving effects in specific scenarios.
  • Profound neutropenia coupled with severe, life-threatening infections poses a significant clinical challenge.

Purpose of the Study:

  • To provide an expert opinion on the appropriate use of granulocyte transfusions.
  • To outline recommendations for granulocyte transfusion protocols in critical care settings.
  • To highlight the importance of cell dose and daily evaluation for granulocyte transfusions.

Main Methods:

  • Expert opinion based on clinical experience and literature review.
  • Consideration of granulocyte transfusions for patients with profound neutropenia and refractory severe infections.
  • Utilizing apheresis for granulocyte donation from mobilized donors (using G-CSF and steroids) or relatives/regular donors.

Main Results:

  • Granulocyte transfusions should be considered when standard antibiotic or antifungal therapies fail in patients with severe infections and neutropenia.
  • The clinical effect of granulocyte transfusions appears to be dose-dependent, necessitating a high cell count in the concentrate.
  • Daily granulocyte transfusions are recommended as long as the clinical indication persists.

Conclusions:

  • Granulocyte transfusions represent a potentially crucial therapeutic option for select patients with life-threatening infections and profound neutropenia.
  • Optimizing granulocyte concentrate dose through donor mobilization with G-CSF and steroids is essential for maximizing efficacy.
  • Continuous daily administration and daily clinical evaluation are critical components of successful granulocyte transfusion therapy.