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Published on: June 23, 2023
Synthesis, antiamoebic activity and docking studies of metronidazole-triazole-styryl hybrids
Beena Negi1, Prija Poonan1, Mohammad Fawad Ansari2
1Department of Chemistry, University of Delhi, Delhi, 110007, India.
Abstract:
A series of 22 novel metronidazole-triazole-styryl hybrids were synthesized and evaluated for their in vitro antiamoebic activity against HM1: IMSS strain of Entamoeba histolytica. Some of the hybrids were found to be more active (IC50 = 0.12-0.35 μM) than the reference drug metronidazole (IC50 = 1.79 μM). The most active compounds were found to be non-toxic (up to 50 μM) against the Vero cells showing a good safety profile of these hybrids. The docking and ADMET studies were also conducted to investigate the probable mode of action. Docking studies showed significant binding affinity in the active site of E. histolytica thioredoxin reductase (EhTrR) protein.
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