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[Curative effect of ozone hydrotherapy for pemphigus]
Fuqiong Jiang1, Danqi Deng1, Xiaolan Li1
1Department of Dermatology, Second Affiliated Hospital, Kunming Medical University, Kunming 650101, China.
Summary
Ozone hydrotherapy, an aid for pemphigus vulgaris, reduced antibiotic use and improved patient satisfaction. This treatment is safe and effective, complementing standard therapies like glucocorticoids.
Area of Science:
- Dermatology
- Immunology
- Medical Therapy
Background:
- Pemphigus vulgaris is an autoimmune blistering disease requiring significant medical intervention.
- Standard treatments include glucocorticoids and immune inhibitors, often associated with side effects and complications.
- Exploring adjunctive therapies to improve outcomes and reduce treatment burden is crucial.
Purpose of the Study:
- To evaluate the clinical efficacy of ozone hydrotherapy as an adjunctive treatment for pemphigus vulgaris.
- To compare ozone hydrotherapy with potassium permanganate solution in managing pemphigus vulgaris.
- To assess the impact on lesion healing, bacterial infection, antibiotic usage, and patient satisfaction.
Main Methods:
- A randomized controlled trial comparing ozone hydrotherapy (n=32) with potassium permanganate soaks (n=34) as an aid to standard treatment for pemphigus vulgaris.
- Both groups received glucocorticoids and immune inhibitors as primary therapy.
- Outcomes assessed included clinical curative effect, hospital stay duration, bacterial infection rates, antibiotic use, and patient satisfaction.
Main Results:
- No significant difference was observed in the overall clinical curative effect or hospital stay duration between the two groups.
- Ozone hydrotherapy group showed a statistically significant reduction in antibiotic usage (P=0.039).
- Patients in the ozone hydrotherapy group reported higher satisfaction after 7 days of treatment compared to the control group (P>0.05).
Conclusions:
- Ozone hydrotherapy is a safe and effective adjunctive treatment for pemphigus vulgaris.
- This therapy can lead to a decreased need for antibiotic administration in patients with pemphigus vulgaris.
- Ozone hydrotherapy offers a beneficial option for improving patient experience in pemphigus vulgaris management.
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