Related Experiment Video
Updated: Feb 13, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
Published on: April 4, 2014
Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds
Duc N Tran1, Claudio Battilocchio1, Shing-Bong Lou1
1Innovative Technology Centre , Department of Chemistry University of Cambridge , Lensfield Road , Cambridge , CB2 1EW , UK .
Abstract:
The work takes advantage of an important feature of flow chemistry, whereby the generation of a transient species (or reactive intermediate) can be followed by a transfer step into another chemical environment, before the intermediate is reacted with a coupling partner. This concept is successfully applied to achieve a room temperature sp2-sp3 cross coupling of boronic acids with diazo compounds, these latter species being generated from hydrazones under flow conditions using MnO2 as the oxidant.
More Related Videos
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Coupled Reactions
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
Crossed Aldol Reactions: Overview
Crossed Aldol Reaction Using Weak Bases
β-Dicarbonyl Compounds via Crossed Claisen Condensations
Crossed Aldol Reaction Using Strong Bases: Directed Aldol Reaction