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Updated: Feb 13, 2026

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
Published on: February 23, 2016
A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy
Victor Sans1, Luzian Porwol1, Vincenza Dragone1
1WestCHEM , School of Chemistry , The University of Glasgow , Glasgow G12 8QQ , UK . Email: Lee.Cronin@glasgow.ac.uk ; http://www.croninlab.com.
Abstract:
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including 19F, 13C, DEPT, 2D NMR spectroscopy (COSY, HSQC and 19F-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.
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