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Altered network hub connectivity after acute LSD administration.

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Lysergic acid diethylamide (LSD) alters brain connectivity, decreasing within-network function while increasing between-network communication. These changes, particularly involving brain hubs, may explain hallucinogen effects on mental health.

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Brain Imaging

Background:

  • Lysergic acid diethylamide (LSD) has complex effects on mental health, potentially mimicking psychosis or improving anxiety and depression.
  • Neuronal correlates of LSD-induced altered consciousness are poorly understood.
  • Previous studies suggest LSD significantly alters resting-state functional connectivity.

Purpose of the Study:

  • To replicate and extend previous findings on LSD's effects on brain functional connectivity.
  • To investigate alterations in within-network and between-network connectivity after acute LSD administration.
  • To explore the role of brain hubs in LSD's effects.

Main Methods:

  • Double-blind, randomized, cross-over study with 20 healthy participants.
  • Oral administration of 100 μg LSD and placebo.
  • Resting-state functional magnetic resonance imaging (fMRI) to assess brain activity.
  • Analysis of within-network and between-network connectivity across ten resting-state networks.

Main Results:

  • Acute LSD administration significantly decreased functional connectivity within visual, sensorimotor, auditory, and default mode networks.
  • Between-network connectivity generally increased across all investigated networks.
  • Seed-to-voxel analyses revealed increased connectivity between networks and key subcortical (thalamus, striatum) and cortical (precuneus, ACC) hub structures.

Conclusions:

  • LSD induces significant alterations in large-scale brain network connectivity.
  • Increased connectivity with hub structures may be crucial for understanding LSD's psychopathological and potential therapeutic effects.
  • Findings support models proposing hub involvement in hallucinogen-induced states and therapeutic potential.