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Updated: Feb 13, 2026

In vivo Dual Substrate Bioluminescent Imaging
Published on: October 11, 2011
Visualization of mercury(ii) accumulation in vivo using bioluminescence imaging with a highly selective probe
1Laboratory of Anaesthesiology & Critical Care Medicine, West China Brain Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Abstract:
Mercury is a highly toxic environmental pollutant that negatively affects human health. Thus, an in vivo method for noninvasive imaging of mercury(ii) and visualization of its accumulation within living systems would be advantageous. Herein, we describe a reaction-based bioluminescent probe for detection of mercury(ii) in vitro and accumulation in vivo. The application of this probe would help to shed light on the intricate contributions of mercury(ii) to various physiological and pathological processes.
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