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Published on: April 14, 2010
Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine
Eva Ramos1, Alejandro Romero1, Javier Egea2
1Department of Pharmacology & Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid 28040, Spain.
Aim:
The 1,8-naphthyridine CR80 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b] [1,8]naphthyridine-3-carboxylate) has shown interesting neuroprotective properties in in vitro and in vivo models of neurodegeneration. In spite of these promising outcomes, the molecular and cellular mechanisms underlying CR80 actions need to be further explored.
Materials & Methods:
We herein report the signal transduction pathways involved in developmental, neuroprotective and stress-activated processes, as well as the gene expression regulation by CR80 in SH-SY5Y neuroblastoma cells.
Results:
The CR80 exposure upregulated several antioxidant enzymes (HO-1, GSR, SQSTM1, and TRXR1) and anti-apoptotic proteins (Bcl-xL, Bcl-2, P21, and Wnt6).
Conclusion:
The observed changes in gene expression would afford new insights on the neuroprotective profile of CR80.
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