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[Microcirculation in patients with paranoid schizophrenia]
A V Sakharov1, A S Ozornin2, S E Golygina2
1Chita State Medical Academy, Chita, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|March 22, 2018
Summary
Laser Doppler flowmetry revealed significant microcirculation changes in paranoid schizophrenia patients, indicating accelerated blood flow and heightened local regulatory mechanisms that persisted after three weeks of therapy.
Area of Science:
- Neuroscience
- Medical Physiology
- Psychiatry
Background:
- Paranoid schizophrenia is a complex psychiatric disorder.
- Understanding its impact on the body's circulatory system is crucial for comprehensive patient care.
- Microcirculatory dysfunctions may play a role in the pathophysiology of schizophrenia.
Purpose of the Study:
- To investigate microcirculation alterations in patients diagnosed with paranoid schizophrenia.
- To assess the impact of therapy on these microcirculatory changes.
Main Methods:
- Utilized laser Doppler flowmetry, a noninvasive technique, to analyze microcirculation.
- Examined 53 patients with paranoid schizophrenia (F20.0) in acute psychotic states and after 3 weeks of treatment.
- Included a control group of 20 healthy volunteers for comparison.
Main Results:
- Identified significant microcirculation changes in patients that persisted for at least three weeks of therapy.
- Observed a 1.4-fold increase in the total microcirculation index, suggesting accelerated blood flow.
- Noted a 3.7-fold increase in average perfusion fluctuations and a 1.9-fold increase in the coefficient of variation, indicating enhanced local regulatory mechanisms.
Conclusions:
- Microcirculation is significantly altered in patients with paranoid schizophrenia.
- These alterations, including accelerated blood flow and heightened local regulation, persist despite three weeks of therapy.
- Findings suggest a role for microcirculatory dysregulation in the pathophysiology and ongoing state of paranoid schizophrenia.
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