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Updated: Feb 13, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
NH3 and (NH2)1- as ligands in yttrium metallocene chemistry
Monica D Boshart1, Joseph W Ziller1, William J Evans1
1Department of Chemistry, University of California, Irvine, CA 92697-2025, USA. wevans@uci.edu.
Abstract:
(C5Me5)2Y(C3H5)(THF) reacts with ammonia in THF to form the first crystallographically-characterized rare-earth metal complex with a terminal (NH2)1- ligand, (C5Me5)2Y(NH2)(THF), 1. Complex 1 can be protonated with [HNEt3][BPh4] to form [(C5Me5)2Y(NH3)(THF)][BPh4], 2. Both complexes were characterized by X-ray crystallography which allowed a comparison of the Y-NH2 bond length, 2.226(2) Å, with an Y-NH3 bond length, 2.476(2) Å, in analogous coordination environments. Reactions of 2 with NaN3 and acetone produced the known complexes [(C5Me5)2YN3]x and [(C5Me5)2Y(OCMe2)2][BPh4], respectively, suggesting that the ammonia moiety in 2 functions as a displaceable solvate like THF.
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