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Updated: Feb 13, 2026

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles
Published on: June 25, 2018
Anti-tumour active gold(i), palladium(ii) and ruthenium(ii) complexes with thio- and selenoureato ligands: a
Anja Molter1, Stefanie Kathrein2, Brigitte Kircher3
1Fakultät für Mathematik und Naturwissenschaften, Anorganische Chemie, Bergische Universität Wuppertal, 42119 Wuppertal, Germany. fmohr@uni-wuppertal.de.
Abstract:
We report the results of a comparative study of the biological activity of a series of gold(i), palladium(ii) and ruthenium(ii) complexes containing deprotonated thio- and selenoureato ligands. A library of compounds was prepared and characterised by spectroscopic methods and the solid-state structures of several derivatives were determined by single crystal X-ray diffraction. The in vitro activity of these compounds was evaluated in mammary and ovarian carcinoma, acute lymphatic and acute and chronic myeloid leukemia cell lines. At lower concentrations Ru- and Pd-containing compounds displayed stronger anti-cancer effects than the gold compounds. In all cases, the selenium derivatives proved to be more active than the corresponding sulfur compounds.
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