The Management of Critically Colonized and Locally Infected Leg Ulcers with an Acid-Oxidizing Solution: A Pilot Study

Area of Science:

• Wound healing research
• Antimicrobial therapies
• Clinical case series

Background:

• Chronic wounds often present with critical colonization or local infection, posing clinical challenges.
• Limited therapeutic options exist for these conditions, necessitating novel treatment approaches.

Purpose of the Study:

• To evaluate the antimicrobial properties and wound healing support of a new acid-oxidizing solution (AOS).
• To assess the tolerability and performance of AOS in patients with chronic leg ulcers.

Main Methods:

• An open-label, prospective, single-arm case series involving 30 patients with chronic leg ulcers.
• AOS was applied to leg ulcers during dressing changes for 35 days.
• Assessed ulcer characteristics, bioburden, local infection, pain, pH, and wound healing.

Main Results:

• AOS was well-tolerated with no adverse events reported.
• Significant reductions in local infection, wound bed pH, and wound area were observed.
• Patient pain decreased significantly, and 37% of patients achieved complete ulcer resolution.

Conclusions:

• AOS demonstrates potential as a tolerable and effective treatment for supporting wound healing in locally infected chronic ulcers.
• Further investigation through larger controlled cohort studies is recommended to validate these findings.