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Myocarditis in autopsy.

R Okada, S Wakafuji

    Heart and Vessels. Supplement
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study analyzed Japanese autopsy records from 1958-1977, finding a rise in myocarditis cases, particularly after 1974. Pathological findings in myocarditis and postmyocarditic cardiomegaly cases revealed significant ventricular changes and inflammation.

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    Area of Science:

    • Pathology
    • Cardiology
    • Epidemiology

    Background:

    • Autopsy records from Japan (1958-1977) contain 377,841 cases with pathologic findings.
    • Myocarditis diagnoses, including idiopathic, interstitial, viral, and giant-cell types, were identified.

    Purpose of the Study:

    • To analyze the incidence and pathological characteristics of myocarditis and postmyocarditic cardiomegaly (PMC) in a large Japanese autopsy cohort.
    • To investigate trends and histological features associated with these cardiac conditions over a 20-year period.

    Main Methods:

    • Retrospective analysis of 377,841 autopsy records from Japan (1958-1977).
    • Identification and classification of myocarditis and PMC cases.
    • Histopathological examination of cardiac tissues to determine structural and inflammatory changes.

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    Main Results:

    • A total of 409 (0.11%) myocarditis cases and 25 (0.007%) giant-cell myocarditis cases were registered.
    • Myocarditis incidence showed variations at 5-year intervals, with a notable increase after 1974.
    • Analysis of 19 myocarditis and 19 PMC cases revealed male predominance. Acute/subacute myocarditis showed ventricular dilatation, interstitial mononuclear infiltration, necrosis, and myocyte disarray. Chronic myocarditis/PMC exhibited hypertrophy, ventricular dilatation, fibrosis, and residual inflammation.

    Conclusions:

    • Myocarditis incidence in Japan increased significantly after 1974.
    • Histopathological findings in myocarditis and PMC cases indicate distinct patterns of ventricular remodeling, inflammation, and fibrosis.
    • The study highlights the importance of autopsy data in understanding the epidemiology and pathology of myocarditis.