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The developing gut microbiota and its consequences for health

M-J Butel1, A-J Waligora-Dupriet1, S Wydau-Dematteis1

  • 1Paris Descartes University, Sorbonne Paris Cité, Faculty of pharmacy,Hospital-University Department «Risk in pregnancy»,Team "Intestinal ecosystem, Probiotics, Antibiotics",Paris,France.

Journal of Developmental Origins of Health and Disease
|March 23, 2018
PubMed

Insights

The first 1000 days are critical for gut microbiota development. Early gut dysbiosis, influenced by perinatal factors, can lead to long-term health issues like allergies and obesity.

Area of Science:

  • Microbiology
  • Developmental Biology
  • Immunology

Background:

  • The first 1000 days (conception to 2 years) are crucial for health and disease development.
  • Gut microbiota establishment occurs during this critical window.
  • Perinatal factors like delivery mode, feeding, and antibiotic use significantly impact early gut colonization and can lead to dysbiosis.

Purpose of the Study:

  • To explore the impact of early life gut microbiota establishment on long-term health outcomes.
  • To investigate the potential role of the in-utero placental microbiota in fetal immune programming.
  • To highlight the link between neonatal gut microbiota and future disease risk.

Main Methods:

  • Review of existing literature on the developmental origins of health and disease.
  • Analysis of studies investigating perinatal determinants of gut microbiota.
  • Examination of research on placental microbiota and its potential influence on fetal development.

Main Results:

  • Early gut dysbiosis, resulting from perinatal factors, can have persistent effects and increase the risk of diseases such as allergies and obesity.
  • Recent findings suggest a potential in-utero microbiota, particularly in the placenta, which may influence fetal immune development.
  • Alterations in placental microbiota composition have been associated with pregnancy complications.

Conclusions:

  • The establishment of the neonatal gut microbiota is intrinsically linked to future health.
  • The placental microbiota may play an earlier role in immune programming than previously understood.
  • Interventions like prebiotics and probiotics are promising for preventing or correcting early dysbiosis to mitigate long-term health consequences.

Keywords:
diseasesestablishmentgut microbiotahealthneonates

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