Skin-Resident T Cells Drive Dermal Dendritic Cell Migration in Response to Tissue Self-Antigen
Niwa Ali1,2, Bahar Zirak1, Hong-An Truong1
1Department of Dermatology, University of California, San Francisco, San Francisco, CA 94143.
Journal of Immunology (Baltimore, Md. : 1950)
|March 23, 2018
Summary
Skin-resident effector T cells drive dendritic cell migration to lymph nodes during autoimmune responses. This Batf3-dependent dendritic cell (DC) migration is crucial for initiating skin autoimmunity.
Area of Science:
- Immunology
- Dermatology
- Autoimmunity
Background:
- Dendritic cells (DCs) migrate to lymph nodes to regulate immune responses.
- Signals controlling DC migration in response to self-antigens are not well understood.
- CD103+ dermal DCs (DDCs) are key players in skin immunity.
Purpose of the Study:
- To investigate the signals that mediate DC migration in response to tissue self-antigen.
- To elucidate the role of T cells in driving DC migration during autoimmune responses.
Main Methods:
- Mouse model of inducible skin-specific self-antigen expression.
- Genetic deletion and adoptive transfer of immune cells.
- Analysis of DC migration and T cell activation in skin and draining lymph nodes.
Main Results:
- CD103+ DDCs rapidly migrate from skin to draining lymph nodes within 48 hours of self-antigen expression.
- Activation of skin-resident effector T cells (Teffs) is required to drive CD103+ DDC migration.
- Batf3-dependent DDCs are essential for initiating a potent autoimmune response in the skin.
- Teff activation in draining lymph nodes does not influence DDC migration.
Conclusions:
- Skin-resident Teffs provide crucial signals that drive CD103+ DDC migration to lymph nodes.
- This T cell-dependent DC migration is a critical step in the elicitation phase of skin autoimmune responses.
- Understanding these mechanisms could inform new therapeutic strategies for autoimmune diseases.
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