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Updated: Feb 13, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

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Vascular endothelial growth factor suppresses dendritic cells function of human prostate cancer

Wen-Kun Bai1, Wei Zhang1, Bing Hu1

  • 1Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.

Oncotargets and Therapy
|March 23, 2018
PubMed
Abstract

Insights

Vascular endothelial growth factor (VEGF) inhibits dendritic cell (DC) function in prostate cancer (PCa). This inhibition worsens with increasing PCa malignancy, impairing anti-tumor immunity.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Prostate cancer (PCa) is associated with impaired dendritic cell (DC) function.
  • The underlying mechanisms for these DC defects in PCa remain unclear.

Purpose of the Study:

  • To investigate the role of vascular endothelial growth factor (VEGF) in the function of mature dendritic cells (DCs) within the context of prostate cancer.

Main Methods:

  • Comparative analysis of peripheral blood T cells, prostate tissue dendritic cells (composition and function), and local VEGF density.
  • Study included patients with PCa, prostatic intraepithelial neoplasia (PIN), and benign prostatic hyperplasia (BPH).

Main Results:

  • PCa patients exhibited reduced numbers of total, mature, and functional DCs, along with decreased CD4+ T cells.
  • VEGF-positive cell infiltration increased with higher PCa malignancy.
  • Inhibition of DC function was identified as a mechanism for suppressed anti-tumor immunity in PCa.

Conclusions:

  • VEGF significantly inhibits dendritic cell maturation and function.
  • The inhibitory effect of VEGF on DCs intensifies with increasing prostate cancer malignancy.
Keywords:
T celldendritic cellimmunologyprostate cancervascular endothelial growth factor

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