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Updated: Feb 13, 2026
05:20
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
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Prenatally detected thoracic neuroblastoma
Yejin Park1, Hyun Jin Lee1, Yun Ji Jung1
1Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Obstetrics & Gynecology Science
|March 23, 2018
Summary
Fetal thoracic neuroblastoma, a rare condition, was detected via prenatal ultrasound, presenting as a lung mass with significant pleural effusion. Early diagnosis and intervention are crucial for managing this pediatric cancer.
Area of Science:
- Pediatric Oncology
- Fetal Medicine
- Radiology
Background:
- Neuroblastoma is a common pediatric extracranial solid tumor originating from neural crest cells.
- Thoracic neuroblastomas are less common, and fetal detection is rare.
Observation:
- A rare case of fetal thoracic neuroblastoma was identified at 30 weeks gestation via prenatal ultrasonography.
- The fetus presented with a right thoracic mass and massive pleural effusion, initially suspected as teratoma.
- Progressive mass growth, worsening pleural effusion, and fetal hydrops indicated malignancy.
Findings:
- Post-cesarean delivery, neonatal ultrasonography revealed a 4 cm mass with calcification and hemothorax.
- Excision biopsy confirmed the diagnosis of neuroblastoma.
Implications:
- This case highlights the importance of prenatal diagnosis for rare fetal thoracic tumors.
- Early detection of fetal neuroblastoma can guide timely management and improve outcomes.
- Prenatal ultrasonography is vital for identifying thoracic masses and associated complications in fetuses.
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