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Updated: Feb 13, 2026

Denaturing Urea Polyacrylamide Gel Electrophoresis Urea PAGE
Published on: October 29, 2009
Modulating the physical properties of solid forms of urea using co-crystallization technology
Bhupinder Sandhu1, Abhijeet S Sinha1, John Desper1
1Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA. aakeroy@ksu.edu.
Abstract:
The solid-form landscape of urea was explored using full interaction maps (FIMs) and data from the CSD to develop optimum protocols for synthesizing co-crystals of urea. As a result, 49 of the 60 attempted reactions produced new co-crystals, and the crystal structures of four of these are presented. Moreover, the goal of reducing the solubility and lowering the hygroscopicity of the parent compound was achieved, which in turn offers new opportunities for application as a slow-release fertilizer with limited hygroscopicity, thereby reducing many current problems of transport, handling, and storage of urea.
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