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Intravitreal Injections in the Ovine Eye
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[Systemic safety following intravitreal injections of anti-VEGF]

S Baillif1, B Levy2, J-F Girmens3

  • 1Département d'ophtalmologie, hôpital Pasteur, 30, voie Romaine, 06000 Nice cedex 1, France.

Journal Francais D'Ophtalmologie
|March 24, 2018
PubMed

Insights

Intravitreal anti-vascular endothelial growth factors (anti-VEGFs) injections are unlikely to cause systemic adverse events. Safety data and pharmacokinetic studies suggest these side effects are rare in ophthalmology, despite concerns from cancer trials.

Area of Science:

  • Ophthalmology
  • Pharmacology
  • Clinical Trials

Background:

  • Intravitreal anti-vascular endothelial growth factors (anti-VEGFs) are used to treat various eye conditions.
  • Concerns exist regarding potential systemic adverse events (AEs) similar to those seen in oncology.

Purpose of the Study:

  • To evaluate the likelihood of systemic AEs following intravitreal anti-VEGF injections.
  • To assess the consistency of pharmacokinetic and pharmacodynamic data regarding systemic drug diffusion.

Main Methods:

  • Review of safety data from ophthalmology clinical trials.
  • Analysis of pharmacokinetic and pharmacodynamic studies on systemic anti-VEGF distribution.

Main Results:

  • Systemic AEs, such as hypertension and proteinuria, are infrequently reported in ophthalmology trials.
  • Pharmacokinetic/pharmacodynamic data show inconsistencies, questioning significant systemic exposure.
  • Current evidence suggests systemic events post-intravitreal injection are highly improbable.

Conclusions:

  • Intravitreal anti-VEGF therapy appears safe concerning systemic adverse events.
  • Further research is necessary to fully understand local and systemic effects of anti-VEGFs.
Keywords:
AfliberceptBevacizumabBévacizumabInjections intravitréennesIntravitreal injectionsPharmacocinétiquePharmacodynamicsPharmacodynamiquePharmacokineticsRanibizumabTolerabilityTolérance

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