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Triple-component nanocomposite films prepared using a casting method: Its potential in drug delivery
Sadia Gilani1, Sadullah Mir2, Momina Masood1
1Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
Journal of Food and Drug Analysis
|March 24, 2018
Summary
This study developed chitosan-polyethylene glycol (PEG) nanocomposite films for drug delivery. Higher PEG concentrations enhanced piroxicam-β-cyclodextrin release and skin permeation, showing potential for localized delivery.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Chitosan-based nanocomposites are promising for drug delivery.
- Polyethylene glycol (PEG) can modify nanocomposite properties.
- Piroxicam-β-cyclodextrin is a model drug for anti-inflammatory applications.
Purpose of the Study:
- To fabricate chitosan-PEG nanocomposite films.
- To evaluate their potential for drug delivery.
- To investigate the effect of PEG molecular weight on film characteristics.
Main Methods:
- Casting/solvent evaporation method for film preparation.
- Characterization using XRD, SEM, TGA, and FTIR.
- In vitro drug release, swelling, water content, and anti-inflammatory activity tests.
- Ex vivo permeation studies using Franz diffusion cell.
Main Results:
- Film properties and drug release were sensitive to pH and ionic strength.
- Increased PEG concentration correlated with higher swelling, water content, and drug permeation.
- Formulation F10 (75% PEG) exhibited optimal swelling, permeation, and in vitro release.
- Significant anti-inflammatory effect was observed with the developed films.
Conclusions:
- Chitosan-PEG nanocomposite film composition significantly impacts drug release.
- PEG molecular weight influences swelling, drug release, and permeation rates.
- These developed films show promise for localized transdermal drug delivery.
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