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Applicability of 2008 World Health Organization classification system of hematolymphoid neoplasms: Learning

Sushil Modkharkar¹, Pooja Navale¹, Pratibha Kadam Amare²

¹Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Indian Journal of Pathology & Microbiology

|March 24, 2018

Abstract

Background:

2008 World Health Organization (WHO) classification of hematolymphoid neoplasms (HLN) has classified them based on morphology, results of various ancillary techniques, and clinical features.^[1] There are no studies looking at the applicability of WHO classification.

Aims:

The aim of the study was to calculate proportions of all HLN subtypes seen during 1-year period based on 2008 WHO classification of HLN and study applicability and also shortcomings of practices in a tertiary care center in India.

Materials And Methods:

This was a 1-year retrospective study (January 1^st, to December 31^st, 2010) where cases were identified using hospital/laboratory electronic records. Old follow-up and referral cases were excluded from the study. Only newly diagnosed cases classified into categories laid down by 2008 WHO classification of HLN included.

Results:

Out of 2118 newly diagnosed classifiable cases, 1602 (75.6%) cases were of lymphoid neoplasms, 489 (23.1%) cases of myeloid neoplasms, 16 (0.8%) cases of histiocytic and dendritic cell neoplasms, and 11 (0.5%) cases of acute leukemias of ambiguous lineage. Overall, most common HLN subtype was diffuse large B-cell lymphoma (n = 361, 17.0%). Precursor B-lymphoblastic leukaemia/lymphoma (n = 177, 48.2%) was the most common subtype within pediatric age group.

Conclusions:

All major subtypes of HLN were seen at our center and showed trends almost similar to those seen in other Indian studies. Molecular/cytogenetic studies could not be performed on a significant number of cases owing to logistic reasons (unavailability of complete panels and also cost-related issues) and such cases could not be classified as per the WHO classification system.

Keywords:

Extranodal lymphomas World Health Organization classification hematolymphoid neoplasms leukemia lymphoma pediatric hematolymphoid neoplasms

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