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Updated: Feb 12, 2026

Patterning of Embryonic Stem Cells Using the Bio Flip Chip
Published on: October 1, 2007
A wide-band bio-chip for real-time optical detection of bioelectromagnetic interactions with cells
Caterina Merla1,2, Micaela Liberti3, Paolo Marracino3
1Laboratory of Vectorology and Anticancer Therapies, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, 114 rue E. Vaillant, 94805, Villejuif, France. caterina.merla@enea.it.
Abstract:
The analytical and numerical design, implementation, and experimental validation of a new grounded closed coplanar waveguide for wide-band electromagnetic exposures of cells and their optical detection in real-time is reported. The realized device fulfills high-quality requirements for novel bioelectromagnetic experiments, involving elevated temporal and spatial resolutions. Excellent performances in terms of matching bandwidth (less than -10 dB up to at least 3 GHz), emission (below 1 × 10-6 W/m2) and efficiency (around 1) have been obtained as revealed by both numerical simulations and experimental measurements. A low spatial electric field inhomogeneity (coefficient of variation of around 10 %) has been achieved within the cell solutions filling the polydimethylsiloxane reservoir of the conceived device. This original bio-chip based on the grounded closed coplanar waveguide concept opens new possibilities for the development of controlled experiments combining electromagnetic exposures and sophisticated imaging using optical spectroscopic techniques.
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