Malignant lymphoma, large cell immunoblastic clear cell showing unusual histologic picture

A case of malignant lymphoma, large cell, immunoblastic clear cell (WF) in a 59-year-old woman was reported. This patient showed no remarkable symptoms except generalized lymphadenopathy and slightly elevated serum levels of IgG and IgM. Histologic examinations were performed twice at about 6 months interval. Marked differences were noticed between the period, and they were histopathologically interesting and unusual findings. By immunological staining in situ, T-clear cells showed a subset marker of helper/inducer's characteristics. It was suggested that this case was different from AILD-like T-cell lymphoma in histogenesis. The results of marker study and the changes in histopathological morphology among two biopsied specimens were presented.