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Updated: Feb 12, 2026
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
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Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
1Dry Powder Inhaler Lab, Respiratory Formulations, Cipla R&D, LBS Marg Road, Vikhroli (West), Mumbai, Maharashtra 400079, India.
Journal of Drug Delivery
|March 24, 2018
Summary
Inhalation therapy, used for pulmonary diseases, faces challenges with drug delivery. This review explores new carriers and formulation strategies to improve inhaled medication performance.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Respiratory Medicine
Background:
- Inhalation therapy has a long history, primarily for treating pulmonary diseases like asthma.
- Traditional formulations use carriers like alpha-lactose monohydrate, often with inadequate pulmonary deposition and dispersion.
- Current limitations necessitate advancements in inhaled drug formulation.
Purpose of the Study:
- To review alternative carrier molecules for inhalation therapy.
- To discuss advanced formulation strategies for improved aerodynamic performance.
- To explore recent advances, challenges, and future directions in inhalation therapy.
Main Methods:
- Literature review of scientific publications on inhalation therapy.
- Analysis of carrier materials and powder processing techniques.
- Discussion of formulation strategies for enhanced drug delivery.
Main Results:
- Identified limitations in traditional inhalation formulations regarding drug deposition and dispersion.
- Highlighted various alternative carriers and advanced formulation techniques.
- Discussed the potential of these innovations to improve aerodynamic performance.
Conclusions:
- There is a need for more suitable and economical carrier molecules in inhalation therapy.
- Advanced formulation strategies are crucial for optimizing pulmonary drug delivery.
- Continued research into novel carriers and processing methods is essential for future progress.
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