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Published on: January 27, 2014
A divergent and concise total synthesis of (-)-lycoposerramine R and (+)-lycopladine A
Sheng Chen1, Jinming Wang1, Fayang G Qiu1
1Guangzhou Institute of Biomedicine and Health, The Chinese Academy of Sciences, 190 Kaiyuan Ave., The Science Park of Guangzhou, Guangdong 510530, China. qiu_fayang@gibh.ac.cn and The University of The Chinese Academy of Sciences, Beijing, 100049, China.
Abstract:
A concise, asymmetric and divergent synthesis of lycoposerramine R and lycopladine A is presented. The synthesis features the palladium-catalyzed cycloalkenylation of a silyl enol ether for assembling the 5/6-hydrindane system and generating a quaternary carbon center in one step.
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