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Updated: Feb 12, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
Published on: April 9, 2019
Initial series of magnetic resonance imaging (MRI)-fusion targeted prostate biopsy using the first transperineal
Christopher D Kosarek1, Ali M Mahmoud1, Eduardo J Eyzaguirre2
1Division of Urology, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Objectives:
To describe a step-by-step guide for using the first transperineal targeted prostate biopsy platform available in the USA.
Patients And Methods:
A total of 32 men with elevated prostate-specific antigen (PSA) levels were diagnosed with a region of interest on multiparametric magnetic resonance imaging (mpMRI) between February 2017 and January 2018. The transperineal targeted prostate biopsy procedure was accomplished via a transperineal approach and used a stepper, combined with advanced mpMRI/transrectal ultrasound fusion software, to perform targeted prostate biopsy. The detection of overall and clinically significant prostate cancer (PCa) was assessed as well as the rate of complications.
Results:
The median patient age was 68.0 years and the median PSA was 8.0 ng/mL. Two patients (6%) were active surveillance candidates and 16 (50%) had a prior negative prostate biopsy. The detection rates for overall and clinically significant PCa were 81% and 59%, respectively. The two candidates for active surveillance and eight of the patients with a prior negative prostate biopsy had clinically significant PCa confirmed on targeted biopsy. There were no peri-operative complications.
Conclusion:
These results demonstrate the promising potential of the first transperineal targeted prostate biopsy platform in the USA as an alternative diagnostic method for PCa.
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