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Updated: Feb 12, 2026

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Dynamic alterations of hepatocellular function by on-demand elasticity and roughness modulation
K Uto1, T Aoyagi2, C A DeForest3
1International Center for Young Scientists (ICYS), National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. UTO.Koichiro@nims.go.jp and PRIME, Japan Agency for Medical Research and Development, Tokyo 100-0004, Japan.
Abstract:
Temperature-responsive cell culture substrates reported here can be dynamically programmed to induce bulk softening and surface roughness changes in the presence of living cells. Alterations in hepatocellular function following temporally controlled substrate softening depend on the extent of stiff mechanical priming prior to user-induced material transition.
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