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    Researchers developed a versatile nanosecond multiphasic pulse generator for plasma medicine. This new device allows for flexible control over pulse polarity and waveform, enhancing biological stimulation applications.

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    Area of Science:

    • Biophysics
    • Electrical Engineering
    • Biomedical Engineering

    Background:

    • Nanosecond electric pulses are crucial for plasma medicine and biological stimulation.
    • Current uniphasic pulse generators limit the modulation of biological effects.
    • Reversing pulse polarity offers unique control over cellular responses.

    Purpose of the Study:

    • To develop a multimodal nanosecond pulse generator for biomedical applications.
    • To demonstrate the ability to cancel or enhance cell swelling and blebbing.
    • To create flexible and versatile pulse waveforms for advanced research.

    Main Methods:

    • A modular generator design using capacitors and MOSFET switches.
    • Series stacking of modules to achieve up to 5 kV voltage.
    • Parallel configuration of stacks for multiphase output generation.
    • Independent control and charging of each stack for waveform versatility.

    Main Results:

    • Successfully generated nanosecond multiphasic pulses.
    • Demonstrated control over cell swelling and blebbing by adjusting pulse parameters.
    • Achieved flexible and versatile pulse waveforms through modular design.
    • The circuit topology supports high-frequency uniphasic or biphasic nanosecond burst pulses.

    Conclusions:

    • The developed generator provides a novel tool for precise control in plasma medicine.
    • Offers significant potential for applications in electroporation, tissue ablation, and wound healing.
    • Opens new avenues for nonthermal plasma generation and advanced biomedical research.