Related Experiment Video

Updated: Feb 12, 2026

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

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Long-term outcomes of mitral valve annuloplasty versus subvalvular sparing replacement for severe ischemic mitral

Baotong Li1, Hengchao Wu1, Hansong Sun2

  • 1State Key Laboratory of Cardiovascular Disease, Department of Adult Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Science, Peking Union Medical College, Beijing, China.

Cardiology Journal
|March 24, 2018
PubMed

Insights

For severe chronic ischemic mitral regurgitation (CIMR), subvalvular sparing mitral valve replacement (MVR) shows better ventricular remodeling and fewer heart failure hospitalizations compared to mitral valve annuloplasty (MVA). Long-term outcomes were similar for major adverse events and survival.

Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Cardiac Surgery Outcomes

Background:

  • Severe chronic ischemic mitral regurgitation (CIMR) management guidelines recommend surgery but lack specificity regarding valve repair versus replacement.
  • Mitral valve annuloplasty (MVA) and subvalvular sparing mitral valve replacement (MVR) are surgical options for severe CIMR.

Purpose of the Study:

  • To compare the long-term clinical outcomes of MVA versus subvalvular sparing MVR in patients with severe CIMR.

Main Methods:

  • Retrospective review of 392 patients with severe CIMR undergoing MVA or subvalvular sparing MVR.
  • Multivariable regression analysis and propensity score matching (77 pairs) were used to adjust for baseline differences.

Main Results:

  • No significant difference in major adverse cardiac or cerebrovascular events (MACCE), cardiac death, or all-cause death between MVA and MVR groups after adjustment.
  • MVA group showed larger left atrium/ventricle diameters and higher mitral regurgitation recurrence rates.
  • Subvalvular sparing MVR was associated with a lower incidence of heart failure hospitalization compared to MVA.

Conclusions:

  • Subvalvular sparing MVR is a suitable option for severe CIMR, promoting better ventricular remodeling.
  • MVR demonstrates a reduced rate of heart failure hospitalization compared to MVA in this patient cohort.
Abstract

Keywords:
chronic ischemic mitral regurgitationcoronary artery bypass graftingmitral valve annuloplastsubvalvular sparing mitral valve replacement

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