Related Experiment Video
Updated: Feb 12, 2026

Design and Construction of an Urban Runoff Research Facility
Published on: August 8, 2014
Expedient Construction of the Hexacycle of Franchetine
Zhengchao Lv1, Lingzhi Gao1, Chuanxu Cheng1
1Key Laboratory of Drug Targeting, Ministry of Education Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China.
Abstract:
Franchetine, a unique 7,17-seco type of norditerpenoid alkaloid, possesses a highly congested polycyclic architecture coupled with nine stereogenic centers. Here we present an efficient synthetic approach for the intact hexacyclic framework of franchetine from the known tricyle 16 in 20 steps. The synthesis features a diastereoselective 6-exo-tet radical cyclization for construction of ring A and a unique oxidative Wagner-Meerwein-type rearrangement to realize the functionalized [3.2.1] bridging ring CD.
Related Concept Videos
Construction of Root Locus
For positive gain values, the root locus exists on the real axis to the left of an odd number of finite open-loop poles or zeros. The root locus starts at the open-loop poles and traces the paths of the closed-loop poles as the gain...
Construction of Frequency Distribution
First, make a table with two columns—one with the title of the data that needs to be organized, and the other column for frequency. [Draw a third column for tally marks if needed]. Then, take a look at the items given in the data set and decide if an ungrouped frequency distribution table or a grouped frequency distribution table would be more suitable. If there are large sets of different values, then it is...
Bode Plots Construction
Design Example: Dimensioning of Concrete Masonry Construction
The site engineer has laid out a plan for the storeroom with external dimensions of twelve feet in length and...
X-ray Crystallography
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
The Sense of Self: Reflected Self-Appraisal and Social Comparison

