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Three-dimensional echocardiographic ventricular mass/end-diastolic volume ratio in native hypertensive patients:

Maria Lembo1,2, Roberta Esposito1,2, Ciro Santoro1,2

  • 1Hypertension Research Center (CIRIAPA).

Journal of Hypertension
|March 24, 2018
PubMed

Insights

Three-dimensional echocardiography effectively identifies left ventricular (LV) concentric geometry in hypertensive patients. Reduced stroke volume, detected by the LV mass/end-diastolic volume (LVM/EDV) ratio, indicates early myocardial dysfunction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Hypertension Research

Background:

  • Elevated left ventricular (LV) mass/end-diastolic volume (LVM/EDV) ratio is linked to myocardial fibrosis and dysfunction in hypertensive patients.
  • Cardiac magnetic resonance (CMR) is a diagnostic tool but has limited availability.

Purpose of the Study:

  • To assess the capability of three-dimensional (3D) echocardiography in identifying LV concentric geometry using the LVM/EDV ratio.
  • To detect early myocardial damage in native hypertensive patients.

Main Methods:

  • 128 native hypertensive patients underwent 2D and 3D echocardiography.
  • Patients were grouped based on 3D-LVM/EDV ratio cut-off values (1.22 in men, 1.23 in women) derived from 90 healthy individuals.
  • Statistical analyses, including multilinear regression, were performed.

Main Results:

  • 3D echocardiography identified a higher prevalence of LV concentric geometry (37%) compared to 2D-derived relative wall thickness (24%, P=0.03).
  • Patients with elevated LVM/EDV ratio were older, had smaller LV volumes, and higher LV mass index, but similar ejection fraction.
  • Stroke volume was independently and negatively associated with the LVM/EDV ratio (β=-0.55, P<0.0001).

Conclusions:

  • 3D echocardiography-derived LVM/EDV ratio detects a greater prevalence of LV concentric geometry in hypertensive patients than 2D methods.
  • Reduced stroke volume, associated with the LVM/EDV ratio, serves as an early indicator of myocardial dysfunction in hypertensive patients with LV concentric geometry.
Abstract

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